Radiesse is made from calcium hydroxyapatite spheres reconstituted in an aqueous solution. It injects very easily and creates immediate results. After injection, as the water is absorbed by the body, new collagen synthesis is stimulated around the hydroxyapatite spheres to create a long lasting effect, reportedly 1-2 years. Radiesse is not suggested for use around the lips. Radiesse comes in a 1.5cc syringe, more volume (more correction) in each syringe than any of the other leading brand dermal fillers.