A lot of factors contribute to wrinkles: heredity, smoking, unhealthy diet, sun damage, a negative attitude about life, but in large part, wrinkles appear because collagen disappears.

To understand the relation between skin wrinkles and collagen, first it’s necessary to understand what collagen is. Collagen is a fibrous protein, mainly present in skin, bones, muscles, and cartilage. Collagen supports and connects organs to the bones. It is the “glue that keeps the body together”.

Collagen and Elastin (a protein that gives elasticity to our organs) are responsible for the resilience and elasticity of the skin. Thanks to them, the skin is able to stretch every time we make a move and revert to its original position.
As we get older, collagen production is diminished and the skin begins to lose its elasticity and its capacity to retain moisture. Expression lines become more pronounced due to skin sagging, and those expression lines become wrinkles. The skin begins to sag because it loses its flexibility and resilience. The older we get, the deeper the wrinkles.
Studies have shown that estrogen, progesterone and HGH hormone therapies have a positive affect on reducing wrinkles.